Efficacy of picroliv in combination with miltefosine, an orally effective antileishmanial drug against experimental visceral leishmaniasis

The picroliv per se showed no antileishmaial potential. However, when given with suboptimal dose of miltefosine, it enhanced efficacy of the latter from 45 to 86% on day 7 post treatment and from 32 to 64% on day 28 post treatment. Interestingly, the effectivity of this combination was as good as that of the curative dose of miltefosine alone. Thus, this combination appears to offer a fruitful strategy for treatment of VL.