An illustrated heuristic prototype facilitates scientific inventive problem solving: A functional magnetic resonance imaging study

•Role of heuristic prototypes in solving scientific invention problems was studied.•Prototype illustrations facilitated the solving of scientific invention problems.•Higher activation was found in the RMTG, RPCG and LMFG when illustrations were used.•β-values of RMOG and RPCG were positively correlated with imagination score.

Many scientific inventions (SI) throughout history were inspired by heuristic prototypes (HPs). For instance, an event or piece of knowledge similar to displaced water from a tub inspired Archimedes’ principle. However, the neural mechanisms underlying this insightful problem solving are not very clear. Thus, the present study explored the neural correlates used to solve SI problems facilitated by HPs. Each HP had two versions: a literal description with an illustration (LDI) and a literal description with no illustration (LDNI). Thirty-two participants were divided randomly into these two groups. Blood oxygenation level-dependent fMRI contrasts between LDI and LDNI groups were measured. Greater activity in the right middle occipital gyrus (RMOG, BA19), right precentral gyrus (RPCG, BA4), and left middle frontal gyrus (LMFG, BA46) were found within the LDI group as compared to the LDNI group. We discuss these results in terms cognitive functions within these regions related to problem solving and memory retrieval.