| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9278027 | FEMS Immunology and Medical Microbiology | 2005 | 6 Pages |
Abstract
Bacterial virulence is greatly enhanced by freely available iron, such as that in fully-saturated transferrin or free haemoglobin. Following trauma a fall in tissue Eh and pH due to ischaemia, plus the reducing powers of bacteria, can make iron in transferrin freely available and abolish the bactericidal properties of tissue fluids with disastrous results for the host. Hyperbaric oxygen is a possible therapeutic measure that could restore normal bactericidal systems in infected tissues by raising the Eh and pH.
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Authors
John J. Bullen, Henry J. Rogers, Paul B. Spalding, Charles G. Ward,