| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9279519 | Journal of Virological Methods | 2005 | 9 Pages |
Abstract
In this study, a novel rBCG delivery system is described using non-integrative plasmids harboring hepatitis B surface antigen genes. This rBCG was able to elicit an anti-HBs response in BALB/c mice. The titres of anti-HBs response obtained using rBCG was relatively lower than that of the commercial vaccine used as positive control. In vivo or in vitro stability assays showed that the vector used to generate rBCG is stable in spite of being a non-integrative plasmid. In addition, the HBsAg proteins expression profiles were almost similar to those obtained using an Escherichia coli expression system.
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Authors
Cleide Aparecida Ferreira Rezende, Marcia Terezinha Baroni De Moraes, Denise Cristina De Souza Matos, Douglas Mcintoch, Geraldo Rodrigues Garcia Armoa,