| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9282956 | Microbes and Infection | 2005 | 13 Pages |
Abstract
Tuberculosis remains a global health concern. Control of infection is dependent on cell-mediated immune responses, with CD4+ T lymphocytes playing a central role. In this article, data supporting the importance of CD8+ T lymphocytes is reviewed, with an emphasis on the unique functional roles that this lymphocyte subset may play.
Keywords
Major histocompatibilty complexCD8-Positive T-LymphocytesRNILTBIIFNγMTBTSTBCGNOSBacillus Calmette-GuérinTuberculin skin testHuman leukocyte antigenHLAAntigen presentationinterferon-gammaTuberculosistumor necrosis factor-alphatransporter associated with antigen processingWorld Health OrganizationDendritic cellendoplasmic reticulumTAPlatent TB infectionTNF-αMycobacterium tuberculosisMHCnitric oxide synthasereactive nitrogen intermediatesWHO
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Authors
Jeff E. Grotzke, David M. Lewinsohn,