| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9283008 | Microbes and Infection | 2005 | 7 Pages |
Abstract
Coxsackieviruses are a cause of clinical myocarditis. Both virus replication and host defense mechanisms, including virus-induced autoimmunity, mediate heart injury and cardiac dysfunction. Vγ4+ cells kill infected cardiocytes and virus-specific CD4+ Th2 cells through Fas-dependent apoptosis and CD1d. The CD4+ Th1 response is necessary for activation of the autoimmune CD8+ T cells, which kill uninfected cardiocytes through perforin-dependent mechanisms.
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Authors
S.A. Huber, Willi Born, Rebecca O'Brien,