Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9286645 | Virology | 2005 | 5 Pages |
Abstract
Infection with oncogenic human papillomavirus (HPV) is considered to be the major risk to cervical cancer. This study analyzed the influence of HPV infection on cytokine intralesional levels in cervical lesion in the presence or not of HIV infection. Cervical biopsies from 42 women were studied. HPV detection and typing were performed using amplified DNA hybridized with sequence-specific primers, and cytokine intralesional levels were detected using ELISA. HPV16+ biopsies exhibited increased IFN-γ and IL-10 when compared to HPV16â (P = 0.03 and 0.04, respectively). HPV18+ biopsies exhibited decreased TNF-α (P = 0.009) and IFN- γ (P = 0.01) when compared to HPV18â. In accordance to HIV status, HIVâ/HPV16+ patients exhibited increased IFN-γ when compared to those presenting HIVâ/HPV16â (P = 0.007). HIVâ/HPV18+ patients presented decreased IFN-γ when compared to HIVâ/HPV18â (P = 0.02). These results suggest that the presence of HPV16 infection may influence cervical lesion installation, and irrespective of HIV status, HPV18 infection may be more aggressive than HPV-16.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Ana Paula M. Fernandes, Maria Alice G. Gonçalves, Geraldo Duarte, Fernando Q. Cunha, Renata T. Simões, Eduardo A. Donadi,