Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9286743 | Virology | 2005 | 9 Pages |
Abstract
Respiratory syncytial virus (RSV) is a major cause of lower airway disease in infants and children. Immunity to RSV is not long lasting, resulting in re-occurring infections throughout life. Effective long-lived immunity results when central-memory T cells that proliferate vigorously and secrete IL-2 are present. In contrast, effector-memory T cells that mainly produce IFN-γ, facilitate virus clearance but are not long lived. To identify the type of memory response induced after RSV-A (Long) infection, we characterized the kinetics of the antigen-specific immune response and identified the types of cytokines induced. RSV-specific lymphocytic proliferation following primary and secondary infection was similar, and in both cases responses waned within a short period of time. In addition, mRNA for IFN-γ but not IL-2 was induced in RSV-specific CD4+ T cells. This supports the idea that the presence of effector-memory rather than central-memory T cells contributes to the ineffectiveness of the immune response to RSV.
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Authors
Bettina W.M. Richter, Jaya M. Onuska, Stefan Niewiesk, Gregory A. Prince, Maryna C. Eichelberger,