Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9286792 | Virology | 2005 | 7 Pages |
Abstract
Codon volatility is defined as the proportion of a codon's point-mutation neighbors that encode different amino acids. The cumulative volatility of a gene in relation to its associated genome was recently reported to be an indicator of selection pressure. We used this approach to measure selection on all available full-length HIV-1 subtype B genomes in the Los Alamos HIV Sequence Database, and compared these estimates against those obtained via established likelihood- and distance-based comparative methods. Volatility failed to correlate with the results of any of the comparative methods demonstrating that it is not a reliable indicator of selection pressure.
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Virology
Authors
Satish K. Pillai, Sergei L. Kosakovsky Pond, Christopher H. Woelk, Douglas D. Richman, Davey M. Smith,