| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9286844 | Virology | 2005 | 6 Pages |
Abstract
Latent Epstein-Barr virus (EBV) infection is strongly associated with B-cell proliferative diseases such as Burkitt's lymphoma. Here we show that the oncogenic serine/threonine kinases Pim-1 and Pim-2 enhance the activity of the viral transcriptional activator EBNA2. During EBV infection of primary B-lymphocytes, the mRNA expression levels of pim genes, especially of pim-2, are upregulated and remain elevated in latently infected B-cell lines. Thus, EBV-induced upregulation of Pim kinases and Pim-stimulated EBNA2 transcriptional activity may contribute to the ability of EBV to immortalize B-cells and predispose them to malignant growth.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Eeva-Marja Rainio, Helena Ahlfors, Kara L. Carter, Marja Ruuska, Sampsa Matikainen, Elliott Kieff, Päivi J. Koskinen,