Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9288370 | Virology | 2005 | 11 Pages |
Abstract
Memory CD8+ T cells are comprised of CD122hi IL-15-dependent and CD122lo IL-15-independent subsets. Induction and retention of IL-15-independent memory CD8+ T cells was assessed in IL-15â/â and wild-type (wt) mice immunized with recombinant vaccinia virus (rVV) or Sindbis virus (rSIN) vectors expressing the identical foreign epitope. Both vectors induced epitope-specific CD8+ T cell expansion and function, independent of IL-15. Similar kinetics of rVV clearance confirmed effective CD8+ T cell function in IL-15â/â mice. CD44hi CD122hi CD8+ T cells, mainly of the CD62Lâ/lo phenotype, increased more dramatically and declined more rapidly in IL-15â/â mice, independent of the vector. Rapid IL-15-independent memory CD8+ T cell expansion following challenge of immune mice compensated for the limited memory CD8+ populations in IL-15â/â mice. However, despite expansion and expression of potent effector function, viral clearance was delayed in the absence of IL-15, coinciding with a rapid loss in cytolytic function.
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Authors
Jun Zuo, Stephen A. Stohlman, Cornelia C. Bergmann,