Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9289282 | Virus Research | 2005 | 7 Pages |
Abstract
A number of viral proteins have the property to penetrate into the cells when present in the extra-cellular compartment. Here, we report that the Epstein-Barr virus (EBV) transcriptional activator EB1/Zta, which is responsible for the activation of the EBV lytic replication, binds to lymphoid cells surface, is efficiently translocated and accumulates in the nucleus. The internalization of EB1/Zta is energy-dependent and shares common features with endocytosis. As the EB1/Zta was not degraded in the cells and reached the nucleus, the potential effect of its internalisation on viral reactivation was assessed.
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Virology
Authors
Ségolène Mahot, Pascal Fender, Romain R. Vivès, Cécile Caron, Monique Perrissin, Henri Gruffat, Alain Sergeant, Emmanuel Drouet,