Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9289494 | Virus Research | 2005 | 11 Pages |
Abstract
L-Zagreb nucleotide and deduced protein sequences were compared with other mumps virus sequences obtained from the GenBank. Emphasis was put on functionally important protein regions and known antigenic epitopes. The extensive comparisons of nucleotide and deduced protein sequences between L-Zagreb vaccine strain and other previously determined mumps virus sequences have shown that while the functional regions of HN, V, and L proteins are well conserved among various mumps strains, there can be a substantial amino acid difference in antigenic epitopes of all proteins and in functional regions of F protein. No molecular pattern was identified that can be used as a distinction marker between virulent and attenuated strains.
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Authors
Jelena Ivancic, Tanja Kosutic Gulija, Dubravko Forcic, Marijana Baricevic, Renata Jug, Majda Mesko-Prejac, Renata Mazuran,