Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9297770 | Medicina Clínica | 2005 | 9 Pages |
Abstract
Celiac disease is manifested by an enteropathy caused by intolerance to gluten, a family of proteins found in wheat and other cereals. Following intestinal T-cell activation in predisposed individuals, different inflammatory mechanisms are triggered under the control of the cytokine balance including those with a pro-inflammatory Th1 pattern such as IFNγ, TNFα, IL-15 and IL-18; and regulatory cytokines such as TGFβ and IL-10. These cytokines, besides increasing the intensity of the activation and the number of immune cells within the intestinal mucosa, regulate the activity of epithelial growth factors and metalloproteinases, a group of molecules involved in the maintenance and turnover of the intestinal mucosa structure; in inflammatory conditions, they also induce the intestinal lesion responsible for malabsorption syndrome.
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Authors
Alberto J. León, José A. Garrote, Eduardo Arranz,