Article ID Journal Published Year Pages File Type
9299682 Medicine 2005 7 Pages PDF
Abstract
Infections have exerted a strong selective pressure on the evolution of the human immune system, the different components of which have evolved to resist infection by particular micro-organisms. An increasing number of individual human genes that influence the outcome of specific infections have been identified. Deficiency of specific components of the immune system (as a result of either genetic or acquired disorders) predisposes to characteristic patterns of infection. The immune response may also contribute to the pathogenesis of infectious disease.
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