Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9306963 | Actas Urológicas Españolas | 2005 | 9 Pages |
Abstract
Cold ischemia is the best known method to preserve kidneys for transplant. However, it produces several detrimental effects. First, cellular necrosis. Secondarily, during the hypothermic period a mithocondrial injury process develops which makes the cell entering a pre-apoptotic state. This apoptosis occurs definitively in the reperfusion. Preservation solutions currently available are not perfect and are not able to avoid cold-related cell injuries. The adition of certain substances to UW solution (desferrioxamine) has shown experimentally a reduction in mitochondrial cold-related lesions. Isolated hypothermic kidney perfusion reduces initial graft dysfunction about 20% in comparison to hypothermic storage. This fact relates to important either economical as functional consequences.
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Authors
E. Lledó GarcÃa, G. Pedemonte, C. Hernández Fernández, I. Berenguer GarcÃa, D. RodrÃguez MartÃnez, J.F. Del Cañizo López,