Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9307794 | Advances in Chronic Kidney Disease | 2005 | 9 Pages |
Abstract
Accumulating research suggests that oxidative stress is a significant contributor to the pathogenesis of diabetic nephropathy. The normal kidney generates a substantial amount of oxidative stress because of its high metabolic activity that is balanced by an extensive antioxidant system. However, in pathologic states such as hyperglycemia, nitroso-oxidant balance shifts toward a pro-oxidant state that accelerates tissue and vascular injury. This oxidative damage progresses concomitant with worsening glucose metabolism, vascular dysfunction, and kidney disease. Accordingly, strategies to reduce oxidative stress in diabetes mellitus may exert favorable effects on the progression of diabetic nephropathy.
Related Topics
Health Sciences
Medicine and Dentistry
Nephrology
Authors
Nina Vasavada, Rajiv Agarwal,