Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9308274 | Kidney International | 2005 | 9 Pages |
Abstract
Together, these data suggest that, in order to understand the effect of SNPs in genes of the SLC22 family on drug handling as well as excretion of metabolites like uric acid, it is important to consider the entire set of organic anion transporters. It will be particularly interesting to determine if individuals with nonsynonymous apical and basolateral SNPs have altered handling (and toxicity) of organic anionic drugs and metabolites. Certain OAT family members appear to be under greater evolutionary selection pressure.
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Authors
Gang Xu, Vibha Bhatnagar, G.E.N. Wen, Bruce A. Hamilton, Satish A. Eraly, Sanjay K. Nigam,