Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9308283 | Kidney International | 2005 | 7 Pages |
Abstract
Deletion of p27Kip1 attenuates the functional and morphologic features of diabetic nephropathy. Although deletion of p27Kip1 abolished some parameters of diabetic glomerular hypertrophy, the significant reduction of TGF-β1 expression in the tubulointerstitium indicates that other protective mechanisms could be operative. The p27Kip1 gene is haplo-insufficient because diabetic p27Kip1 +/- mice exhibited an intermediate degree of functional and structural renal injury. Our data shows that p27Kip1 plays an important role in diabetic nephropathy.
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Authors
Gunter Wolf, Anja Schanze, Rolf A.K. Stahl, Stuart J. Shankland, Kerstin Amann,