Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9308413 | Kidney International | 2005 | 5 Pages |
Abstract
PR3-ANCA in undiluted serum or plasma from PR3-ANCA-positive WG patients bind to TNFα- primed and PMA-stimulated PMN that express PR3 on their membrane. Therefore, the hypothesis that PR3-ANCA can bind and activate primed PMN is still the most attractive explanation for the contribution of PR3-ANCA to the pathogenesis of Wegener's granulomatosis.
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Authors
Andra P. Van Rossum, Ymke M. van der geld, Pieter C. Limburg, Cees G.M. Kallenberg,