Lipoxin A4 inhibits TNF-α-induced production of interleukins and proliferation of rat mesangial cells

TNF-α-induced proliferation and increment of cyclin E of rat mesangial cells can be inhibited by LXA4, and these inhibitory effects might be through the mechanisms of STAT3 and Akt1/p27kip1 pathway-dependent signal transduction. LXA4 also antagonized TNF-α-stimulated IL-1β and IL-6 synthesis, and these antagonisms were related to SHP-2 and NF-κB pathway-dependent signal transduction.