Variable chronic partial ureteral obstruction in the neonatal rat: A new model of ureteropelvic junction obstruction1

Renal function is impaired by chronic ipsilateral partial UUO, which reduces the number of nephrons, and leads to progressive renal pelvic dilatation. Tubular atrophy and interstitial fibrosis develop prior to significant renal pelvic dilatation. Correlation of clinically measurable parameters with renal morphometry or imaging studies in this model may lead to new approaches to the management of congenital UPJ obstruction. 1See Editorial by Peters, p. 371.