Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9308556 | Kidney International | 2005 | 11 Pages |
Abstract
Diverse forms of renal injury induce dramatic triglyceride loading in proximal tubules/renal cortex, suggesting that this is a component of a cell stress response. PLA2 activity, increased triglyceride/triglyceride substrate (e.g., fatty acid) uptake, and possible systemic cytokine (e.g., from LPS) stimulation, may each contribute to this result. Finally, in addition to being a marker of prior cell injury, accumulation of triglyceride (or of its constituent fatty acids) may predispose tubules to superimposed ATP depletion or oxidant attack.
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Authors
Richard A. Zager, Ali C.M. Johnson, Sherry Y. M.D.,