Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9308569 | Kidney International | 2005 | 11 Pages |
Abstract
Hyperuricemia induces arteriolopathy of preglomerular vessels, which impairs the autoregulatory response of afferent arterioles, resulting in glomerular hypertension. Lumen obliteration induced by vascular wall thickening produces severe renal hypoperfusion. The resulting ischemia is a potent stimulus that induces tubulointerstitial inflammation and fibrosis, as well as arterial hypertension. These studies provide a potential mechanism by which hyperuricemia can mediate hypertension and renal disease.
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Authors
Laura G. Sanchez-Lozada, Edilia Tapia, Jose Santamaria, Carmen Avila-Casado, Virgilia Soto, Tomas Nepomuceno, Bernardo Rodriguez-Iturbe, Richard J. Johnson, Jaime Ph. D.,