| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9308582 | Kidney International | 2005 | 8 Pages |
Abstract
Chronic tubulointerstitial changes develop early after renal transplantation and are associated with reduced kidney function. Risk factors for CAN are arterionephrosclerosis (donor-related), nephrocalcinosis (related to preexisting hyperparathyroidism), a long cold-ischemia time (ischemia-perfusion-related), and acute rejection. Renal functional decline precedes morphologic changes of CAN, expressed as tubular atrophy and interstitial fibrosis.
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Authors
Anke Schwarz, Michael Mengel, Wilfried Gwinner, Joerg Radermacher, Marcus Hiss, Hans Kreipe, Hermann Prof Dr,