Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9308991 | Kidney International | 2005 | 11 Pages |
Abstract
In Cy/Cy kidneys with ADPKD, there was an increase of the proform of caspase-9, an increase in cytochrome c release into the cytosol, and an increase in caspase-2 protein and activity demonstrating involvement of the intrinsic pathway. There was an increase in the proform of caspase-8 demonstrating involvement of the extrinsic pathway. No differences in FasL mRNA were seen suggesting that the extrinsic pathway is independent of the death receptor ligand, FasL.
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Authors
Yunxia Tao, Jun Kim, Melinda Stanley, Zhibin He, Sarah Faubel, Robert W. Schrier, Charles L. Edelstein,