Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9308995 | Kidney International | 2005 | 16 Pages |
Abstract
A profibrotic injury response occurred in mesangial cells exposed to amino acids, with or without high glucose, by formation of AGE, oxidative stress, and activation of the PKC-β and MAP kinase-ERK 1,2 signal pathway. These observations provide new insight into cellular mechanisms of kidney damage produced by excess dietary protein, particularly in diabetes.
Keywords
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Authors
Katherine R. Tuttle, Emily C. Johnson, Sheryl K. Cooney, Robert J. Anderberg, Edward K. Johnson, G. Dennis Clifton, Rick L. Meek,