Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9309007 | Kidney International | 2005 | 8 Pages |
Abstract
The oral administration of lanthanum carbonate to normal rats leads to a more than 10-fold increase of tissue La content in at least some organs, including the liver, lung, and kidney. This increase is further enhanced by the uremic state, per se. Plasma levels are a poor indicator of tissue burden. Given the dramatic tissue levels obtained with this rare earth metal given by the oral route, particularly in liver for absolute values, it is probable that the stimulation by CRF is at least partially explained by an increase in intestinal La absorption. The absorptive pathways involved in intestinal La absorption require further study, including possibly enhancing conditions.
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Authors
Bernard Lacour, Anthony Lucas, Daniel Auchère, Nadya Ruellan, Natalie Mariaud De Serre Patey, Tilman B. Drüeke,