Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9309101 | Kidney International | 2005 | 7 Pages |
Abstract
Complement activation occurs in human ischemic acute tubular necrosis. As in rodents, complement activation along the tubular basement membrane after ischemia appears to occur principally via the alternative complement pathway. Because of this, an inhibitor of the alternative pathway might limit complement activation and inflammation after ischemia/reperfusion, thereby protecting the kidney from ischemic acute renal failure.
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Authors
Joshua M. Thurman, M. Scott Lucia, Danica Ljubanovic, V. Michael Holers,