Article ID Journal Published Year Pages File Type
931040 International Journal of Psychophysiology 2015 7 Pages PDF
Abstract

•Sleep deprivation has become a highly concerned issue.•This total sleep deprivation study has human subjects with a large sample size.•This study built a new connection between hormone changes and mental disorder.•Cortisol level changes were significantly associated with mania disorder.•Cut-off value of cortisol forecasting manic attack was determined as 500.56 nmol/L.

This study aimed to investigate the effects of sleep deprivation on serum cortisol level and mental health and explore the correlations between them in servicemen. A total of 149 out of the 207 Chinese servicemen were randomly selected to go through 24 hour sleep deprivation, leaving the rest (58) as the control group, before and after which their blood samples were drawn for cortisol measurement. Following the procedure, all the participants were administered the Military Personnel Mental Disorder Prediction Scale, taking the military norm as baseline. The results revealed that the post-deprivation serum cortisol level was positively correlated with the factor score of mania in the sleep deprivation group (rSp = 0.415, p < 0.001). Sleep deprivation could significantly increase serum cortisol level and may affect mental health in servicemen. The increase of serum cortisol level is significantly related to mania disorder during sleep deprivation.

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