| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9310732 | Kidney International | 2005 | 11 Pages |
Abstract
PAI-1 can regulate TGF-β expression by binding to uPAR and activating the extracellular-regulated signal kinase (ERK)/MAPK pathway. Therefore, PAI-1 contributes to diabetic nephropathy by regulating TGF-β and renal ECM production and may be a therapeutic target in diabetic nephropathy.
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Authors
Susanne B. Nicholas, Elsa Aguiniga, Yuelan Ren, Jason Kim, Joyce Wong, Nalini Govindarajan, Masakuni Noda, Wei Wang, Yasuko Kawano, Alan Collins, Willa A. Hsueh,