Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9310744 | Kidney International | 2005 | 8 Pages |
Abstract
These findings suggest a new cGMP- and GC-C-independent but PLA2-dependent signaling pathway for these peptides in the kidney. Most likely guanylin and uroguanylin inhibit luminal K+ channels of principal cells of human CCD via this pathway. This depolarization of principal cells consequently reduces the driving force of Na+ and water reabsorption, explaining natriuresis and diuresis caused by these peptides.
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Authors
Aleksandra SinðiÄ, Jochen R. Hirsch, A.N.A. Velic, Hansjürgen Piechota, Eberhard Schlatter,