Observed effect of age and body mass index on total and complexed PSA: Analysis from a national screening program

Both tPSA and cPSA levels increased with age. Across age groups, men with a greater BMI had significantly lower cPSA and tPSA levels. The clinical significance of age-adjusted cutoff levels for PSA in obese men for the diagnosis of prostate cancer should be explored further in future prospective clinical trials.