Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9323488 | Fertility and Sterility | 2005 | 6 Pages |
Abstract
In contrast to the effects of GnRH agonists to reduce chemotherapeutic destruction of primordial follicles, GnRH antagonists do not protect the ovary from the damaging effects of cyclophosphamide. More importantly, GnRH antagonists alone deplete primordial follicles in this murine model, likely through a direct effect on the ovary. Whether these observations apply to other species requires further study.
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Authors
Douglas R. Ph.D., Laura K. M.S., Chad I. M.D.,