Gonadotropin-releasing hormone (GnRH) analogues and the ovary: Do GnRH antagonists destroy primordial follicles?

The study by Danforth et al. shows that gonadotropin-releasing hormone (GnRH) antagonists do not protect ovarian follicles from chemotherapy-induced damage and that GnRH antagonists alone reduce primordial follicle numbers in mice. This article discusses the strengths and limitations of the study by Danforth et al., as well as the potential mechanism of action of GnRH antagonists according to the literature.