Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9325235 | Fertility and Sterility | 2005 | 10 Pages |
Abstract
Mifepristone inhibited cell growth by arresting cell cycle progression at S phase, induced apoptosis through caspase-3 activation, and modulated apoptosis regulatory genes BCL2/BAX and FAS/FASLG in Ishikawa cells. Together, these data imply that the improvement in breakthrough bleeding observed with mifepristone might be due to diminished volume of endometrial tissue similar to that seen with endometrial atrophy.
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Authors
Aimin M.D., Juan C. M.D., Parviz Ph.D., Charles A. M.D., John K. M.D.,