Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9325498 | Fertility and Sterility | 2005 | 6 Pages |
Abstract
Caspase-3 dependent apoptosis occurs in human granulosa cells and activates when follicles begin to leave the resting pool. After initial formation of the antrum, activation of caspase-3 is a normal physiologic process of the follicle during atresia and luteinization. Higher numbers of granulosa cells positive with caspase-3 than cells positive with TUNEL suggest an earlier activation of caspase-3 compared with the DNA fragmentation detected by TUNEL assay and also a longer detection period of caspase-3 than DNA fragmentation in apoptotic granulosa cells.
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Authors
Violeta M.D., M.Sc., Katarina M.D., Ph.D., Mirna M.D., Ph.D., Anamarija M.Sc., Damir M.D., Ph.D.,