Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9326312 | Gynecologic Oncology | 2005 | 11 Pages |
Abstract
Human ITFγ-treated fibroblasts as well as non-neoplastic cervical tissues responded to C. trachomatis with a strong down-regulation of caveolin-1 mRNA and a light up-regulation of C-myc mRNA. These changes were independent of the HPV high-risk types. This study reveals possible mechanisms by which C. trachomatis infection may contribute to neoplastic changes in the transformation of uterine cervix. These possible mechanisms require further evaluation.
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Authors
Thilo Schlott, Helmut Eiffert, Wolfgang Bohne, Jobst Landgrebe, Edgar Brunner, Bettina Spielbauer, Bryan Knight,