Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9327629 | Gynecologic Oncology | 2005 | 6 Pages |
Abstract
The results indicate that there is a close association between weak or strong p16 expressions in ASCUS-categorized smears with the presence of SILs in follow-up biopsies and positive HR-HPV viral loads. Conversely, there is also a clear association between the lack of p16 expression and the absence of significant lesions in follow-up biopsies, but this is not consistent with a negative HR-HPV viral load. It is concluded that p16 expression is an indicator of pathogenic activity of HR-HPV, which is an objective biomarker for clarification of ASCUS-categorized Pap smears in gynecological cytopathology. Furthermore, through comparative analysis, directly visualized p16 immunostaining on smears appears to be a more effective method than HR-HPV viral load for the detection of reactive changes and LSILs from ASCUS-categorized Pap smears.
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Authors
Shin Nieh, Su-Feng Chen, Tang-Yuan Chu, Hung-Cheng Lai, Yaoh-Shiang Lin, Earl Fu, Ching-Hwa Gau,