| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9327655 | Gynecologic Oncology | 2005 | 8 Pages |
Abstract
In cervical cancer, VEGF up-regulates EGF-R and down-regulates IGF-BP3, thus amplifying the cell proliferative activity of EGF-R. This action of VEGF seems to be mediated, directly through EGF-R or indirectly through HPV-E6 in the HPV-positive cancers, while EGF-R up-regulation appears to play a major role in the HPV-negative cervical cancers.
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Authors
Rajesh S. Mathur, Subbi P. Mathur,