| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9327700 | Gynecologic Oncology | 2005 | 6 Pages |
Abstract
Smad7 appears to be upregulated in endometrial cancers compared to normal endometrium. Furthermore, high Smad7 gene expression was associated with a shorter time to recurrence. Given that many endometrial cancers have been shown to be TGF-β-unresponsive, Smad7 should be investigated as a potential target to restore TGF-β responsiveness and limit tumor growth.
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Authors
Sean C. Dowdy, Andrea Mariani, Monica M. Reinholz, Gary L. Keeney, Thomas C. Spelsberg, Karl C. Podratz, Ralf Janknecht,