Article ID Journal Published Year Pages File Type
9328376 Gynecologic Oncology 2005 7 Pages PDF
Abstract
The epigenetically silenced PR-B gene remains sensitive to changes in DNA demethylation and histone acetylation in uterine adenocarcinoma cell lines. Treatment with ADC and/or TSA results in a robust and sustainable PR-B upregulation. These small molecule epigenetic modifying agents may be used to sensitize poorly differentiated, PR-B negative endometrial cancers to progestational therapy.
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Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
Preview
Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines
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