Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9328411 | Gynecologic Oncology | 2005 | 9 Pages |
Abstract
The proteome profiling technique provided a broad-base and effective approach for the identification of protein changes induced by paclitaxel and showed anti-proliferate activity through the membrane death receptor-mediated apoptotic pathway, the mitochondrial-mediated pathway. This study shows the power of proteomic profiling with functional analysis using RNAi technology for the discovery of novel molecular targets and a better understanding of the actions of paclitaxel at the molecular level in cervical carcinoma cells.
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Authors
Keun-Ho Lee, Eun-Kyoung Yim, Chan-Joo Kim, Sung-Eun Namkoong, Soo-Jong Um, Jong-Sup Park,