Article ID Journal Published Year Pages File Type
9334924 Reproductive BioMedicine Online 2005 9 Pages PDF
Abstract
Post-transcriptional mechanisms play an important role in the biology of germ cells, where they control key developmental decisions in cell division, differentiation and death. Because these post-transcriptional controls are cell-type-specific, and often utilize germ-cell-specific RNA-binding proteins, they provide useful diagnostic markers for male infertility and testicular cancer. Investigation of the genetics of male infertility in men and model organisms suggests that disruption of post-transcriptional control mechanisms can cause specific germ cell pathologies, and these studies point to future possible therapeutic routes for restoring spermatogenesis.
Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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