Accelerated partial breast irradiation: A dosimetric comparison of three different techniques

In those treated with 3D-CRT, coverage of the PTV was better with 3D-CRT but varied with the definition used. At the coverage at 90% of the PD, no difference was observed between 3D-CRT and MammoSite™ (which were both better than interstitial). 3D-CRT resulted in better coverage of the PTV compared with MammoSite™ or interstitial brachytherapy techniques. Better PTV coverage with 3D-CRT came at the cost of a higher integral dose to the remaining normal breast. Dosimetrically, the best partial breast irradiation technique appears to depend on the clinical situation. Of the brachytherapy techniques, MammoSite™ appears to be superior in PTV coverage. When comparing MammoSite™ vs. 3D-CRT PTV coverage at 90% of the PD, the difference was not significantly different.