Acute supporative osteomyelitis of the lower jaw in Wolfram syndrome: Report of case and review of literature

Wolfram syndrome is a rare, congenital, multisystem disorder believed to be caused by both mitochondrial and nuclear gene dysfunction. Diabetes insipidus, diabetes mellitus, and vision and hearing defects are the main symptoms associated with this syndrome. Disorders of the urinary tract are also often present. Wolfram syndrome affects males and females equally and may be inherited as an autosomal recessive trait. Here in we report a patient with acute supporative osteomyelitis who suffered from wolfram syndrome. Correction of the baseline ketoacidotic situation and aggressive antiobiotic therapy lead to complete healing of the lesion.