| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9340277 | Oral Oncology Extra | 2005 | 4 Pages |
Abstract
Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.
Keywords
Related Topics
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Medicine and Dentistry
Oncology
Authors
Masamichi Ita, Kenichiro Utida, Hitoshi Nagatsuka, Toshikazu Gondo, Kohsuke Sasaki, Yoshiya Ueyama,