Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9346379 | Ophthalmology | 2005 | 8 Pages |
Abstract
Subconjunctival carboplatin in fibrin sealant is effective in the treatment of transgenic murine retinoblastoma. A single injection of low-dose carboplatin in fibrin sealant was sufficient to induce complete or near-complete intraocular tumor regression in 10 of 11 eyes (91%), with no associated histologic evidence of toxicity. These results suggest that subconjunctival carboplatin in fibrin sealant provides sustained release and could have clinical use in the treatment of intraocular retinoblastoma.
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Authors
Kurtis R. BA, Phyllis K. MD, Candice T. BS, Jake A. BS, Thomas M. MD, Hans E. MD, Henry F. PhD, Joan M. MD,