Article ID Journal Published Year Pages File Type
9346379 Ophthalmology 2005 8 Pages PDF
Abstract
Subconjunctival carboplatin in fibrin sealant is effective in the treatment of transgenic murine retinoblastoma. A single injection of low-dose carboplatin in fibrin sealant was sufficient to induce complete or near-complete intraocular tumor regression in 10 of 11 eyes (91%), with no associated histologic evidence of toxicity. These results suggest that subconjunctival carboplatin in fibrin sealant provides sustained release and could have clinical use in the treatment of intraocular retinoblastoma.
Related Topics
Health Sciences Medicine and Dentistry Ophthalmology
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