Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration

Article ID	Journal	Published Year	Pages	File Type
9348295	Progress in Retinal and Eye Research	2005	32 Pages	PDF

Abstract

We are aware of the many excellent reviews and the earlier work paving the way to our current knowledge and understanding of retinal degeneration, photoreceptor apoptosis and neuroprotection. However, we limited this review mainly to work published in the last 7-8 years and we apologize to all the researchers which have contributed to the field but are not cited here.

Keywords

ONL NMDA GDNF N-methyl-d-aspartate AP-1 XIAP CRALBP AAV SIV p75NTR RPE MFG-E8 IGF-II IAP TrkC APAf-1 A2E IRBP FADD P23H RPE65 RCS VPP Trx PEDF Retinitis pigmentosa HSV-1 PCD Endonuclease G B-cell leukemia/lymphoma 2 ABCR Terminal dUTP nick-end labeling TNFα phenyl-N-tert-butylnitrone PARP-1 PDE6b RAIDD LEDGF TGFβ EPO NGF CNTF N(G)-nitro-l-arginine methyl ester FRA-1 AMD NOS RD1 Bcl-2 PBN RDS MNNG BDNF CDD Dimethylthiourea DMTU FAS/CD95 IL-1b l-NAME ROS AIF erythropoietin Arachidonic acid docosahexaenoic acid retinal pigment epithelium interleukin 1 β transforming growth factor-β TUNEL thioredoxin EndoG death domain tumor necrosis factor receptor superfamily DHA retinal degeneration age-related macular degeneration apoptosis inducing factor apoptotic protease activating factor 1 Pigment epithelium-derived factor nerve growth factor basic fibroblast growth factor lens epithelium-derived growth factor DNA fragmentation factor Brain-derived neurotrophic factor glial cell-derived neurotrophic factor outer nuclear layer Mouse model Programmed cell death inhibitor of apoptosis X-linked inhibitor of apoptosis Nitric oxide nitric oxide synthase Adeno-associated virus Interphotoreceptor retinoid-binding protein cellular retinaldehyde binding protein activator protein-1 BID Royal College of Surgeons Reactive oxygen species Fas receptor glucocorticoid receptor