Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9353963 | Journal of Orthopaedic Research | 2005 | 9 Pages |
Abstract
Conclusion: Our results indicate that fibroblasts in periprosthetic tissues are capable of inducing the differentiation of normal human peripheral blood mononuclear cells to mature osteoclasts by a mechanism that involves both RANKL and TNFα. Suppression of both RANKL and inflammatory cytokines is likely to be required to control periprosthetic osteolysis.
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Authors
A. Sabokbar, I. Itonaga, S.G. Sun, O. Kudo, N.A. Athanasou,